Myosin heavy chain 10 (MYH10 (NM-IIB))

Myosin heavy chain 10 is a conventional non-muscle myosin II motor protein encoded by the MYH10 gene. It functions as an actin-dependent ATPase, generating force for diverse cellular processes including cytokinesis, cell migration, maintenance of cell shape, and polarity[1][5]. NM-IIB is essential for normal cardiac muscle development and is the only non-muscle myosin II isoform expressed in cardiac muscle, where it localized to adherens junctions within intercalated discs[1]. Mutations in MYH10 are associated with developmental defects in the heart and brain, and single nucleotide polymorphisms in MYH10 have been linked to left atrial enlargement[1][5]. NM-IIB is composed of a globular motor domain (ATP and actin binding), a coiled-coil rod for dimerization, and associated light chains. It is ubiquitously expressed, with critical roles in cytoskeleton organization, cell division, and specialized functions such as secretion and cell capping[1][5]. MYH10 should not be confused with the unrelated unconventional myosin-10 (MYO10)[5].

Other names

Non-muscle myosin IIBNM-IIBMYH10Myosin-10NMMHCB

No established mechanism of action for therapeutic inhibition/activation; mechanisms target actin-myosin ATPase or cytoskeletal function in experimental contexts[5]