Target intelligence / Profile preview

Myosin heavy chain 13 (MYH13)

Target: MYH13
Molecular classification: Motor protein, Enzyme (ATPase activity), Cytoskeletal protein

Overview

Myosin heavy chain 13 (MYH13) encodes a superfast myosin isoform with ATPase activity, specialized for rapid and precise contractions in specific striated muscles—most notably the extraocular muscles controlling eye movement, as well as laryngeal and syringeal muscles. It is characterized by its ability to catalyze actin-myosin interactions that lead to high-velocity, low-tension muscle contractions. MYH13 is a member of the myosin heavy chain family, displaying restricted expression compared to other isoforms. Genetic variants have been associated with certain muscle-related disorders, but the protein is not an established therapeutic target or biomarker.

Other names: MyHC-EOMyHC-IILMyHC-eoMyosin-13Myosin heavy chain, skeletal muscle, extraocularMyosin heavy chain, skeletal muscle, laryngealSuperfast myosinExtraocular muscle myosin heavy chainMyosin heavy polypeptide 13, skeletal muscle

Biological functions

Actin bindingMicrofilament motor activityMuscle contractionHigh-velocity, low-tension contractions in specific striated muscles (especially extraocular and laryngeal muscle)

Disease associations

Abnormal retinal correspondenceArthrogryposis, distal, type 2AMutations or functional disturbances may theoretically impact disorders of eye movement or muscle function, but these are not established drug indications.

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