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Target intelligence / Profile preview
Myosin heavy chain 14 (MYH14)
- Target
- MYH14
- Molecular classification
- Motor protein, ATPase enzyme, Cytoskeletal protein, Non-muscle myosin
01
Overview
Myosin heavy chain 14 (MYH14) encodes a conventional non-muscle myosin that is part of the myosin superfamily of actin-dependent motor proteins. These proteins are responsible for generating force and movement in cells by converting chemical energy from ATP hydrolysis into mechanical work. MYH14 participates in cellular processes such as cytokinesis, maintenance of cell shape, cell motility, and specialized activities like secretion. Mutations in MYH14 are causative for certain forms of autosomal dominant hearing impairment (DFNA4A) and other disorders such as peripheral neuropathy and myopathy. Multiple isoforms exist due to transcript variation[1][2][5][7].
- Other names
- MYH14DFNA4DFNA4AMHC16MYH17NMHC II-CNMHC-II-CPNMHHmyosin heavy chain 14non-musclemyosinheavy chain 14myosin-14
02
Biological functions
Cell motilityRegulation of cytokinesisCell shapeActin-based contractionCell polaritySpecialized functions in secretion and capping
03
Disease associations
Hearing loss (autosomal dominant nonsyndromic deafness, DFNA4A)Peripheral neuropathyMyopathyHoarsenessCharcot-Marie-Tooth diseaseColorectal cancer (genetic associations)Meniere's disease
04
Biomarkers
Mutations as a biomarker for autosomal dominant nonsyndromic deafness (DFNA4A) and peripheral neuropathy
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