Myosin heavy chain 14 (MYH14) (MYH14)

Myosin heavy chain 14 (MYH14) encodes a conventional non-muscle myosin protein, specifically the heavy chain of non-muscle myosin IIC.[2][3] As an actin-dependent motor protein, MYH14 functions as a molecular motor that hydrolyzes ATP and generates physical force to regulate diverse cellular processes including cytokinesis, cell motility, cell polarity, and specialized functions such as secretion and receptor capping.[2][5] The protein assembles into bipolar filaments and interacts with actin to produce contractile force essential for cellular architecture and function.[3] MYH14 is particularly critical in auditory cells, where it maintains inner ear cell structure and hearing function.[3] Mutations in the MYH14 gene result in autosomal dominant hearing impairment and have been associated with other clinical phenotypes including peripheral neuropathy, myopathy, and hoarseness.[2] Unlike some myosin family members, MYH14 is not currently recognized as an established therapeutic target for drug development, and no pharmacological agents are known to specifically modulate its activity.

Other names

Myosin-14Non-muscle myosin IICCellular myosin

Not applicable — no drugs currently target this protein