Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Myosin heavy chain 15 (MYH15)
- Target
- MYH15
- Molecular classification
- Other (Cytoskeletal protein, Myosin family, Motor protein)
01
Overview
Myosin heavy chain 15 is a protein encoded by the MYH15 gene in humans. It is a member of the myosin superfamily, specifically a sarcomeric myosin heavy chain isoform. MYH15 acts as a slow-twitch myosin and is found primarily in skeletal muscle, heart, and various brain regions, where it fulfills roles in muscle contraction and cytoskeletal architecture through actin binding and ATP-dependent motor activity[1][2][3][5]. Variants in MYH15 have been associated with genetic disorders involving neuromuscular and cognitive deficits, such as progressive microcephaly with seizures and autosomal recessive deafness[2][4]. The role of MYH15 appears essential for proper muscle development and overall muscle function, though detailed molecular mechanisms remain under active investigation[4][6]. MYH15 is not currently considered a direct therapeutic target, and no specific drugs or targeted modulators of this protein are available in clinical use[2][7].
- Other names
- Myosin-15MYH15KIAA1000Myosin, heavy polypeptide 15myosin-15
02
Biological functions
Muscle contractionActin filament bindingCytoskeletal architectureMuscle developmentMicrofilament motor activityATP binding
03
Disease associations
Microcephaly, progressive, with seizures and cerebral and cerebellar atrophyDeafness, autosomal recessive 102Other (Disorders of muscle development/muscle function)
Beyond the preview
Go deeper on Myosin heavy chain 15 (MYH15).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Myosin heavy chain 15 (MYH15).