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Target intelligence / Profile preview
Myosin Heavy Chain 2 (MYH2)
- Target
- MYH2
- Molecular classification
- Motor protein, Myosin, Actin-binding protein
01
Overview
Myosin heavy chain 2 (MYH2) is a protein encoded by the MYH2 gene in humans. It is a member of the class II myosin heavy chains and plays a critical role in skeletal muscle contraction. MYH2 encodes one of several isoforms of type II skeletal muscle myosins, generating mechanical force by interacting with actin filaments within sarcomeres. Mutations or dysfunctions involving MYH2 can lead to various muscular disorders, including Chronic Progressive External Ophthalmoplegia (CPEO).
- Other names
- IBM3MYHSA2MYHas8MyHC-IIaMYHC2AMYPOPMyosin heavy chain 2 skeletal muscle adult
02
Mechanism of action
N/A
03
Biological functions
Skeletal muscle contractionForce generationSarcomere structureEndochondral bone formation
04
Disease associations
Chronic Progressive External Ophthalmoplegia (CPEO)Muscular disordersSkeletal muscle diseases
05
Safety considerations
Potential for off-target effects on other myosin isoformsChallenges in developing highly specific inhibitorsMusculoskeletal toxicity
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