Myosin heavy chain 8 (MYH8)

Myosin heavy chain 8 (MYH8) encodes a class II myosin motor protein primarily expressed in fetal human skeletal muscle, where it forms part of the hexameric myosin complex essential for muscle contraction[1][6]. MYH8 possesses ATPase enzymatic activity, enabling it to hydrolyze ATP and convert chemical energy into mechanical force through interaction with actin filaments[1][3][7]. Mutations in this gene are causally linked to Trismus-pseudocamptodactyly syndrome, a rare congenital arthrogryposis affecting the jaw and fingers[1][2]. MYH8 is mainly involved in normal muscle development and contraction and is not a common direct therapeutic target or receptor for small molecules or biologics[1][6][7].

Other names

Myosin-8MyHC-perinatalMyHC-periMyHC-pnDA7gtMHC-Ffetal-myosin heavy chainmyosin heavy polypeptide 8, skeletal muscle, perinatalmyosin heavy chain, skeletal muscle, perinatal