Myosin-Ib (MYO1B)

Myosin-Ib (MYO1B) is a member of the class I unconventional myosins, which are single-headed actin-based motor proteins involved in a variety of essential cellular processes. MYO1B consists of three major domains: a head or motor domain (responsible for ATP hydrolysis and force generation along actin filaments), a neck region containing IQ motifs that bind calmodulin, and a long tail that mediates interaction with membranes and lipids. In humans, MYO1B is widely expressed and participates in cellular activities including cell migration, vesicular and membrane trafficking, and dynamic regulation of the actin cytoskeleton. MYO1B plays a critical role in neuronal development, axon formation, and growth cone dynamics, acting as a regulator of membrane-cytoskeleton linkage and actin-based protrusive structures[1][2][3][4][5][6]. Genetic associations link MYO1B to diseases such as colorectal cancer and hereditary deafness, but it is not currently a direct drug target. No drugs or small molecules are known to selectively modulate MYO1B activity, and no specific safety or biomarker considerations have been described for this protein.

Other names

Unconventional myosin-IbMMI-alphaMMIamyr1MYH-1cMyosin I alphaMYO1B variant proteinmyosin-I alpha

Not targeted by approved drugs; no mechanism of drug action described