Myosin IC (MYO1C)

Myosin IC is a **class I unconventional myosin**—an actin-based molecular motor protein with ATPase activity. It is found throughout the cytoplasm and associates with membranes, including the plasma membrane and endosomes, using its pleckstrin homology (PH) domain to bind phosphoinositides. MYO1C supports membrane transport, vesicle trafficking, and remodeling, and is critical in linking the actin cytoskeleton to membrane structures. Its ATP-dependent power stroke features unique kinetics, making it highly responsive to mechanical tension and critical for adapting to cellular forces. In the nucleus, a specific isoform (NM1) regulates chromatin remodeling and gene transcription initiation. MYO1C is essential for processes such as glucose transporter recycling (insulin-stimulated GLUT4 movement), mechanotransduction in sensory hair cells, cell adhesion, and epithelial junction stability. Disease relevance includes its role in non-syndromic hereditary deafness, podocyte and epithelial integrity, and possibly metabolic regulation. This protein is highly conserved and involved in fundamental aspects of cell structure and signaling[2][5][6][7][9].

Other names

Unconventional myosin-IcMMI-betaMMIbmyr2NMIMyoICMyosin I betanuclear myosin IMyosin-Icmyosin-I betamyosin IC

Not applicable or documented for MYO1C directly. Drugs that influence actin dynamics, membrane tension, or insulin signaling could theoretically modulate MYO1C activity indirectly, but direct mechanisms are not described in the literature.