Myosin-Ie (MYO1E)

Myosin-Ie (MYO1E) is a nonmuscle class I myosin protein that acts as an ATP-dependent actin-based molecular motor, critical for intracellular movement, membrane trafficking, and the organization of the cytoskeleton[1][3][5][6]. It is characterized by a long “tail” with SH3 and Pleckstrin Homology (PH) domains, which allow it to bind lipids and interact with multiple proteins[1][2][3][5]. MYO1E is essential for the structure and function of kidney podocyte cells, where it maintains the glomerular filtration barrier; mutations in MYO1E cause inherited forms of nephrotic syndrome and focal segmental glomerulosclerosis[1][3][7]. In mammalian cells, MYO1E is involved in clathrin-mediated endocytosis, trafficking of clathrin-coated vesicles, and rapid rearrangement of actin filaments[2][3]. Overexpression or mutation of MYO1E is implicated in cancer progression (notably lung adenocarcinoma and basal-like breast cancer) and kidney diseases, linking MYO1E to both cytoskeletal integrity and disease pathogenesis[1][3][7][5].

Other names

Myosin 1EHuncM-ICFSGS6unconventional myosin-Iemyosin-ICMYO1E variant proteinmyr3 (rat ortholog)