Myosin IG (MYO1G)

Myosin IG (MYO1G) is a member of the class I unconventional myosin family, encoded by the *MYO1G* gene. It is a plasma membrane-associated, actin-binding cytoskeletal motor protein highly expressed in hematopoietic cells, especially T and B lymphocytes and mast cells. MYO1G regulates immune cell migration, membrane elasticity, and adhesion through modulation of actin-plasma membrane interactions. It is uniquely involved in the immune response by generating membrane tension to facilitate lymphocyte surveillance for rare antigens. As a source of the minor histocompatibility antigen HA-2, MYO1G-derived peptides, when presented by MHC class I molecules (notably HLA-A*0201), can stimulate T cell responses that are implicated in graft-versus-host disease and potentially in immune-mediated therapies against hematologic malignancies. Variants in MYO1G alter the immunogenic peptide, impacting transplant outcomes and immune surveillance. If more information is needed for druggability, crystal structures, or more specific ligand interactions, a deeper search in structural biology or immunotherapy databases would be required.

Other names

MYO1GMyosin IGUnconventional myosin-IgMinor histocompatibility antigen HA-2HA2HLA-HA2MHAGmHag HA-2

Immunologic recognition: Peptides from MYO1G can be presented by MHC class I (e.g., HLA-A*0201) and recognized by T cells. Cell migration modulation: Not targeted directly but indirectly involved in therapies modifying T/B lymphocyte function via antigen presentation.