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Myosin-IIIb (MYO3B)
- Target
- MYO3B
- Molecular classification
- Enzyme (ATPase, actin-dependent motor protein), Protein kinase (contains amino-terminal kinase domain), Other (Myosin superfamily, class III myosin)
01
Overview
Myosin-IIIb (MYO3B) is a member of the class III myosin family, characterized by a unique combination of an amino-terminal protein kinase domain and a conventional myosin motor domain[1][2][6]. This actin-dependent ATPase moves along actin filaments and is primarily expressed in sensory tissues such as photoreceptors and cochlear hair cells[1][2]. Its biological role involves regulating the architecture, actin filament elongation, and morphogenesis of cochlear hair bundles essential for hearing[1][6]. Mutations in MYO3B are linked to autosomal recessive forms of nonsyndromic deafness, reflecting its importance in inner ear function[1][5]. As of now, it is not considered a drug target or clinically actionable molecule, and there are no known drugs interacting with MYO3B.
- Other names
- MYO3BMyosin-IIIbMyosin IIIBProtein kinase, actin-dependent motor protein (context-dependent)
02
Mechanism of action
None known.
03
Biological functions
Regulation of actin filament length and architecture in cochlear hair bundlesProtein kinase activity, transfer of phosphorus-containing groupsElongation of actin in stereocilia tips by transporting actin-regulatory factorsEssential for normal hearing and cochlear hair bundle morphogenesis
04
Disease associations
Inherited deafness: Deafness, Autosomal Recessive 30Autosomal Recessive Nonsyndromic Deafness 36
05
Safety considerations
None documented with respect to drug targeting. The main challenges with MYO3B relate to genetic loss-of-function causing auditory defects, not therapeutic safety
06
Biomarkers
None clinically validated. MYO3B mutations may be associated with rare forms of inherited deafness, but are not standard biomarkers for diagnosis or treatment selection
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