Myosin light chain, phosphorylatable, fast skeletal muscle (MYLPF) (MYLPF)

Myosin light chain, phosphorylatable, fast skeletal muscle (MYLPF) is a regulatory subunit of the fast skeletal muscle myosin complex, essential for the modulation of muscle contraction (UniProt P10916). It functions by binding to the neck region of the myosin heavy chain, where it regulates the ATPase activity and the movement of the myosin head along actin filaments (PubMed: 26003401). MYLPF is particularly important for the staircase effect or post-tetanic potentiation in skeletal muscle, where its phosphorylation increases the sensitivity of the contractile apparatus to calcium (NCBI Gene: 29895). Pathogenic variants in the MYLPF gene are linked to Distal Arthrogryposis type 1G, a disorder characterized by multiple joint contractures and impaired muscle development (OMIM: 600958). Although there are currently no approved drugs that specifically target MYLPF, it remains a key protein for understanding skeletal muscle physiology and developing treatments for congenital myopathies (PubMed: 31513310). The protein's role in fast-twitch fibers makes it a potential focus for therapies aimed at muscle wasting or performance enhancement. Understanding its structural interactions is vital for designing small molecules that could modulate muscle force in various neuromuscular conditions.

Other names

MLC2HUMMLC2BMRLC2MYL11Myosin light chain 2Fast skeletal myosin light chain 2

Regulation of the force and speed of muscle contraction through phosphorylation-dependent modulation of myosin ATPase activity.