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Myosin light chain 6 (MYL6)

Target: MYL6
Molecular classification: Other (Structural protein), Component of cytoskeleton, Motor protein complex subunit

Overview

Myosin light chain 6 is a myosin alkali light chain that forms part of the larger myosin hexameric ATPase motor protein complex, which is integral for force generation and motility in both smooth muscle and a wide variety of non-muscle cells. MYL6 is a non-phosphorylatable regulatory light chain that does not bind calcium and participates in the structural and functional regulation of myosin II, supporting cytoskeletal integrity and cell movement. The MYL6 gene is ubiquitously expressed, especially in smooth muscle and non-muscle tissues, and multiple transcript variants exist. No direct drugs or targeted therapies are currently available for this protein. Note: MYL6 should not be confused with myosin light chain kinase (MYLK), which is an enzyme and a known therapeutic target in some disease contexts.

Other names: Myosin light polypeptide 6LC17MLC-3Myosin light chain A3ESMLCMLC3NMMLC1SM17 kDa myosin light chainMyosin light chain 3Myosin light chain alkali 3Smooth muscle and nonmuscle myosin light chain alkali 6LC17-GILC17-NMLC17ALC17BMLC3SMMyosin nonmuscle p-light chainMyosin smooth muscle p-light chain

Biological functions

Structural component of muscle and non-muscle myosinRegulation of cellular motilityForce generation for cell movementMicrofilament motor activityProtein binding

Disease associations

Cardiovascular disease (potentially involved in smooth muscle-related disorders)Noonan syndrome 2 (association)Adrenal gland pheochromocytoma (association)Other (no strong direct disease link established, but some associations)

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