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Target intelligence / Profile preview
Myosin Light-Chain Kinase 2 (MYLK2)
- Target
- MYLK2
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase
01
Overview
Myosin light-chain kinase 2 (MYLK2), also known as skeletal muscle myosin light chain kinase (skMLCK or MLCK2), is a calcium/calmodulin-dependent serine/threonine protein kinase. It phosphorylates the regulatory light chain of myosin II, initiating muscle contraction in skeletal muscle fibers. MYLK2 plays a critical role in regulating actin-myosin crossbridge cycling. Mutations in MYLK2 are linked to midventricular hypertrophic cardiomyopathy.
- Other names
- KMLCMLCKMLCK2skMLCKskeletal muscle myosin light chain kinase
02
Mechanism of action
Inhibition of MYLK2 activity to prevent myosin light chain phosphorylation and subsequent muscle contraction.
03
Biological functions
Phosphorylation of myosin light chainRegulation of muscle contractionCalcium/calmodulin-dependent signaling
04
Disease associations
Cardiovascular diseaseMidventricular hypertrophic cardiomyopathy
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