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Target intelligence / Profile preview
Myosin light chain kinase pseudogene 1 (MYLKP1)
- Target
- MYLKP1
- Molecular classification
- Pseudogene, Other
01
Overview
Myosin light chain kinase pseudogene 1 (MYLKP1) is a transcribed pseudogene related to the active MYLK gene. It does not encode a functional protein but has been found to regulate the stability of MYLK mRNA, suppressing expression of the smooth muscle myosin light chain kinase. MYLKP1 is transcriptionally upregulated in several cancer types and promotes increased cell proliferation by decreasing smMLCK expression. While not a protein-coding gene or classic therapeutic target, it may serve as a candidate biomarker or a potential novel non-coding RNA target, especially in oncology research, due to its regulatory roles and association with tumorigenesis.
- Other names
- Myosin light chain kinase pseudogene 1MYLKP1MYLK pseudogene 1Myosin, light chain 9, regulatory pseudogene
02
Biological functions
Negative regulation of mRNA stability (specifically for MYLK)Modulator of cell proliferation (in cancer context)
03
Disease associations
CancerOther
04
Safety considerations
Not applicable as a direct drug target; however, as a biomarker, more validation is needed before clinical use
05
Biomarkers
Potential marker for certain cancers, such as colon carcinoma, lung adenocarcinoma
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