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Myosin phosphatase Rho interacting protein pseudogene 1 (MPRIPP1)

Target
MPRIPP1
Molecular classification
Other (Pseudogene)
01

Overview

Myosin phosphatase Rho interacting protein pseudogene 1 (MPRIPP1) is a human pseudogene located on chromosome 3 (genomic position 3:44,579,937, ENSEMBL ID: ENSG00000214820, NCBI Gene ID: 100421374). As a pseudogene, MPRIPP1 shares sequence similarity with functional protein-coding genes (in this case, broadly related to myosin phosphatase Rho-interacting proteins) but has accumulated disabling mutations, such as frameshifts or premature stop codons, rendering it unable to produce a functional protein product. Pseudogenes like MPRIPP1 may sometimes be transcribed into RNA and can indirectly regulate gene expression (for example, via the competing endogenous RNA mechanism or as miRNA decoys), but there are no published reports of such function specific to MPRIPP1. MPRIPP1 is not categorized as a therapeutic target. Key point: MPRIPP1 is a pseudogene and not a druggable receptor, enzyme, transporter, or similar therapeutic target, so it does not meet the criteria generally required for molecular drug targeting or biomarker use in current biomedical contexts.

02

Mechanism of action

None, as this is not a target for drugs.

03

Biological functions

Pseudogenes generally have no protein-coding function, but some may regulate gene expression at the RNA level (e.g., serving as competing endogenous RNAs, miRNA decoys, or RNA interference pathways)
04

Disease associations

Potential regulatory roles in various diseases such as cancer have been described for some pseudogenes, but there is no specific disease role reported for MPRIPP1 itself

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