Myosin regulatory light chain 10 (MYL10)

Myosin regulatory light chain 10 (MYL10) is a member of the myosin light chain family, acting as a regulatory subunit that binds non-covalently to myosin heavy chains through IQ motifs in the neck domain. MYL10 is predicted to contribute both structurally and functionally to myosin holoenzyme assembly, integrity, and regulation of its enzymatic (ATPase) activity. MYL10 is a calcium-binding protein and is related to other myosin light chains that play roles in cell movement, cytoskeletal organization, and smooth muscle contraction. Expression and functional annotation data suggest MYL10 is located in the mitochondrion and may be involved in signaling pathways including cardiac conduction and smooth muscle contraction. Diseases associated with MYL10 are rare; one is juvenile glaucoma, but a direct pathogenetic or therapeutic link is not established[1][2][4]. No drugs are known to directly target MYL10, nor is it currently a direct therapeutic target or biomarker. Despite being a well-annotated gene and protein, MYL10 itself is not currently recognized as a canonical drug target (such as a receptor, enzyme, transporter, etc.). None of the authoritative data sources [2][3] identify it as a pharmacologically actionable or therapeutic target, and no drugs or mechanism of action listings exist for it. Direct disease roles are poorly characterized or lacking. The target name and aliases given are accurate, but its biological and clinical significance as a direct target is extremely limited.

Other names

Myosin light chain 2, lymphocyte-specificPrecursor lymphocyte-specific regulatory light chainMYLC2PLPLRLCMGC3479myosin regulatory light chain 10myosin light chain 2, precursor lymphocyte-specific