Myosin regulatory light chain 12A (MYL12A)

Myosin regulatory light chain 12A (MYL12A) is a non-sarcomeric myosin regulatory light chain, part of the myosin II complex, and is essential for the regulation of both smooth muscle and non-muscle cell contractile activity via phosphorylation[1][2][3][5][6][7][8][9]. MYL12A is involved in key cellular functions including cell movement, cytokinesis, actin cytoskeleton organization, and receptor capping[1][3][5][6][9]. Notably, MYL12A acts as a ligand for CD69, mediating immune cell recruitment to sites of inflammation, and may play a role in DNA damage repair by regulating the availability of apoptosis-antagonizing transcription factor (AATF/Che-1)[5][6]. Dysregulation or altered expression of MYL12A has been implicated in diseases such as cancer, inflammatory and autoimmune conditions, and cardiovascular injury, and continues to be investigated as a prospective therapeutic target and biomarker[1][6].

Other names

Myosin regulatory light chain MRLC3MLCBMRLC3RLCHEL-S-24MLC-2BMYL2BMRCL3Myosin RLCMyosin regulatory light chain 2, nonsarcomericepididymis secretory protein Li 24myosin, light chain 12A, regulatory, non-sarcomeric

Not applicable; MYL12A activity is regulated by post-translational modification (phosphorylation by myosin light chain kinase (MLCK) and Rho-associated kinase (ROCK))[1] Potential for drug action via modulation of CD69-MYL12A interaction (investigational)