Myosin-Va (MYO5A)

Myosin-Va (MYO5A) is an unconventional myosin, a motor protein that uses ATP hydrolysis to move along actin filaments and to transport intracellular cargo. It is particularly important in melanocytes for transferring melanosomes (pigment-containing organelles) to the cell periphery, and in neurons, where it traffics organelles and proteins and supports exocytosis. MYO5A interacts with Rab27A and melanophilin to form complexes critical for melanosome transport. It can also bind microtubules, acting as a bridge between actin and microtubule cytoskeletons, and may help cross-link and coordinate these systems[1][3][4][5]. Defects or loss-of-function mutations in MYO5A underlie Griscelli syndrome type 1, a rare autosomal recessive disorder characterized by pigment dilution and severe neurological symptoms. Although MYO5A plays important physiological roles, it has not been established as a direct therapeutic drug target, nor are there known drugs designed to modulate its activity[1][3][4].

Other names

dilute myosin heavy chain, non-muscleGS1MYH12MYO5MYO5A_HUMANmyosin VA (heavy chain 12, myoxin)myosin, heavy polypeptide kinasemyosin-12myosin-VamyoxinMYR12unconventional myosin-Va