Myosin VB pseudogene

The myosin VB pseudogene (ENSG00000267591) is classified as a pseudogene—a type of non-functional genomic locus that shares sequence similarity with the functional myosin VB (MYO5B) gene but has acquired disabling mutations or structural changes that prevent it from producing a functional protein[1]. Pseudogenes can be categorized as unitary, unprocessed (duplicated), or processed, with the latter formed via retrotransposition[1]. Pseudogenes, including the myosin VB pseudogene, do not encode functional proteins and are not considered therapeutic targets, receptors, enzymes, or active members of molecular families relevant for drug discovery or clinical decision-making[1]. While functional MYO5B is a class V myosin involved in intracellular cargo transport along actin filaments[2], the pseudogene form does not contribute to these or other biological functions. Pseudogenes may sometimes play regulatory roles or serve as markers in evolutionary, genomic, or transcriptomic analysis, but they are not drug targets and generally lack known roles in disease or clinical biomarkers[1]. There is nothing misspelled in the entry, but as a pseudogene, "myosin VB pseudogene" is often not relevant as a therapeutic or research target, and it should not be confused with the functional MYO5B gene or protein. For the pseudogene itself, there is no known role in disease, pharmacology, or clinical utility[1].

Other names

MYO5B pseudogeneENSG00000267591