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Myosin VIIA (MYO7A)

Target: MYO7A
Molecular classification: Unconventional myosin, Actin-based motor protein

Overview

Myosin VIIA (MYO7A) is an unconventional myosin motor protein crucial for various cellular functions, particularly within the inner ear and retina. In the inner ear, it plays a vital role in the development and maintenance of stereocilia, which are essential for hearing. In the retina, MYO7A is involved in melanosome transport and photoreceptor maintenance. Mutations in MYO7A are associated with Usher syndrome type 1B and nonsyndromic hearing loss, highlighting its importance in sensory function.

Biological functions

Intracellular transportStereocilia development and maintenanceMelanosome traffickingOrganelle traffickingMechanotransduction

Disease associations

Usher syndrome type 1BNonsyndromic hearing loss

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