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Target intelligence / Profile preview
Myotubularin (MTM1)
- Target
- MTM1
- Molecular classification
- Protein Tyrosine Phosphatase Superfamily, Myotubularins, Lipid Phosphatase
01
Overview
Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol (3,5)-bisphosphate [PI(3,5)P2]. It plays a crucial role in muscle cell differentiation and membrane trafficking processes. Mutations in the MTM1 gene cause X-linked myotubular myopathy.
02
Mechanism of action
Dephosphorylation of PI(3)P and PI(3,5)P2
03
Biological functions
Muscle differentiationEndocytosisMembrane traffickingAutophagy regulation
04
Disease associations
X-linked myotubular myopathyCharcot-Marie-Tooth disease
05
Safety considerations
Potential for off-target effects due to phosphatase activity
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