Myotubularin-related protein 10 (MTMR10)

Myotubularin-related protein 10 (MTMR10) is a member of the myotubularin family of proteins, which share structural similarity to protein tyrosine phosphatases but typically act on lipid substrates such as phosphoinositides. MTMR10 itself is predicted to be a catalytically inactive phosphatase, lacking key residues required for enzymatic dephosphorylation of phosphatidylinositol 3-phosphate. It is thought to function as an adaptor or modulator for active members of the myotubularin family, possibly through protein-protein interactions that regulate localization and activity of other family members. MTMR10 is expressed in various tissues, with enrichment in the brain, and, based on studies in C. elegans, may protect neurons from degeneration under stress by supporting dendrite morphology and function. Human MTMR10 is associated with certain disease states such as schizophrenia and interstitial nephritis through genetic studies, although direct causality and functional mechanisms remain unclear. There are no drugs known to specifically target MTMR10, and its current significance is chiefly in understanding basic cellular signaling and disease pathophysiology within the broader context of the myotubularin family.

Other names

MTMR10Myotubularin related protein 10GC15M029019GC15M031231GC15M008408GC15M030938GC15M030919GC15M034071GC15M035402GC15M035755GC15M036164GC15M036589GC15M037035GC15M037499GC15M037972GC15M038546GC15M039209GC15M040172GC15M041701GC15M046509

No known drugs, therefore no defined mechanism of action for drug interaction. Function is likely regulatory/adaptor rather than enzymatic, so would not be a classical drug mechanism.