Myozenin-1 (MYOZ1)

Myozenin-1 (MYOZ1, also known as calsarcin-2) is a Z-disc structural and adapter protein highly expressed in skeletal muscle and to a lesser extent in cardiac tissue[1][3][5]. It binds multiple Z-disc proteins, including α-actinin, γ-filamin, and telethonin, and colocalizes at the sarcomeric Z-line, serving as a molecular hub that stabilizes and organizes the contractile apparatus[1][2][4][5]. MYOZ1 also interacts with calcineurin, modulating its activity and thereby regulating the calcineurin/NFAT signaling pathway important for muscle fiber type differentiation and muscle growth[3][5]. Mutations in the MYOZ1 gene have been linked to various myopathies and cardiac hypertrophy, but do not appear to be major drivers of idiopathic dilated cardiomyopathy[1][3][5]. While MYOZ1 has clear biological roles in muscle structure and function, it is not considered a receptor, enzyme, transporter, or direct therapeutic target at present.

Other names

Calsarcin-2FATZCS-2Filamin-, actinin- and telethonin-binding proteinProtein FATZMYOZ

Null (as MYOZ1 is not a therapeutic target for drugs)