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Target intelligence / Profile preview
Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS)
- Target
- MARCKS
- Molecular classification
- Protein Kinase C Substrate
01
Overview
Myristoylated alanine-rich protein kinase C substrate (MARCKS) is a highly conserved, membrane-associated protein that plays a central role in the regulation of the actin cytoskeleton and various cellular processes. It regulates actin filament crosslinking and structural modulation of the actin cytoskeleton, impacting cell shape, motility, chemotaxis, adhesion, phagocytosis, exocytosis, and endo/exocytosis in neurons and other cells. It also sequesters phosphatidylinositol-4,5-bisphosphate (PIP2) at lipid rafts in quiescent cells; PKC-mediated phosphorylation releases PIP2 for signaling functions such as immune response modulation. It plays roles in neural development including neurite outgrowth and synaptic plasticity, and is also involved in vesicle/granule exocytosis.
02
Mechanism of action
Phosphorylation by PKC or binding to calcium-calmodulin inhibits MARCKS association with both actin filaments and plasma membrane.
03
Biological functions
Actin crosslinking/modulationPIP2 sequestration/releaseCell motility & adhesionRegulation of actin filament crosslinkingStructural modulation of the actin cytoskeletonChemotaxisPhagocytosisExocytosisEndo/exocytosisImmune response modulationNeural developmentNeurite outgrowthSynaptic plasticityVesicle/granule exocytosis
04
Disease associations
Schizophrenia/BipolarAlzheimer's diseaseCancerAutoimmune diseasesInflammationPulmonary inflammationRheumatoid arthritis
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