Myxoma virus M013 protein (M013)

The M013 protein is a viral immunomodulatory factor encoded by the Myxoma virus, a member of the Poxviridae family. It functions as a viral pyrin-only protein (vPOP) that effectively subverts the host's innate immune response by targeting two critical signaling pathways: the inflammasome and the NF-kappaB pathway. Specifically, M013 binds directly to the host protein ASC-1 (apoptosis-associated speck-like protein containing a CARD), preventing the assembly of the inflammasome complex and the subsequent activation of caspase-1 and release of pro-inflammatory cytokines like IL-1beta and IL-18. Additionally, it interacts with the NF-kappaB1 (p105) subunit to inhibit NF-kappaB-mediated transcription of inflammatory genes. Due to its potent anti-inflammatory properties, M013 is being investigated as a therapeutic agent, often delivered via viral vectors like AAV, for the treatment of inflammatory and autoimmune conditions such as uveitis and potentially as part of oncolytic virotherapy strategies.

Other names

M013LViral pyrin-only proteinvPOPMyxoma virus M013