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Target intelligence / Profile preview
N-acetylgalactosamine 4-sulfatase (ARSB)
- Target
- ARSB
- Molecular classification
- Enzyme, Sulfatase, Lysosomal enzyme
01
Overview
N-acetylgalactosamine 4-sulfatase (ARSB) is a lysosomal enzyme that hydrolyzes the 4-sulfate groups from N-acetyl-D-galactosamine 4-sulfate units in chondroitin sulfate and dermatan sulfate. ARSB deficiency causes Mucopolysaccharidosis VI (MPS VI). Recombinant ARSB (galsulfase) is used as enzyme replacement therapy for MPS VI. ARSB also has roles in tumor suppression and cell signaling.
- Other names
- Arylsulfatase Bchondroitinsulfataseacetylgalactosamine 4-sulfatase
02
Mechanism of action
Enzyme replacement therapy; provides functional ARSB to degrade accumulated glycosaminoglycans
03
Biological functions
Glycosaminoglycan catabolismHydrolysis of 4-sulfate groups from N-acetyl-D-galactosamine 4-sulfateExtracellular matrix turnoverTumor suppressionRegulation of cell signaling
04
Disease associations
Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)Lysosomal storage disorderCancer (e.g., colon, breast, prostate)
05
Safety considerations
Infusion-related reactions (Galsulfase)Potential immunogenicity (Galsulfase)
06
Interacting drugs
Galsulfase (Naglazyme®)
07
Biomarkers
Urinary GAG levels (MPS VI)ARSB expression/activity (Cancer prognosis)Versican levels (Cancer microenvironment)
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