Target intelligence / Profile preview

N-acetylglucosaminyltransferase V (GnT-V)

Target: GnT-V
Molecular classification: Enzyme, Glycosyltransferase

Overview

N-acetylglucosaminyltransferase V (GnT-V / MGAT5) is a type II membrane-bound glycosyltransferase enzyme that catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the core α1,6-mannose residue of N-glycan acceptors, forming a β1,6-GlcNAc branch. This modification is crucial for generating complex tri- and tetra-antennary N-glycan structures and influences cell signaling, immune responses, and disease progression, particularly in cancer and autoimmune disorders.

Other names: MGAT5

Mechanism of action

Inhibition of N-glycan branching

Biological functions

Cell surface protein stabilizationSignal potentiationImmune modulationCell proliferationNeural differentiation

Disease associations

CancerAutoimmune disease

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