N-acetylglutamate kinase (NAGK)

N-acetylglutamate kinase (NAGK) is an enzyme that catalyzes the phosphorylation of N-acetylglutamate (NAG) using ATP, producing N-acetylglutamyl phosphate. This reaction is the second step in the arginine biosynthesis pathway in microorganisms and plants. The enzyme's activity is regulated by feedback inhibition by arginine; when arginine levels are high, NAGK is inhibited to reduce arginine synthesis[6][3][4]. Structurally, NAGK forms ring-like oligomeric assemblies (often hexamers or tetramers) with distinct N- and C-terminal domains where the active sites for NAG and ATP are located[4]. There are no direct human diseases associated with NAGK deficiency, as animals do not possess this enzyme in their urea cycle; the human urea cycle uses N-acetylglutamate synthase (NAGS) instead[5]. However, in bacteria and plants, NAGK is essential for de novo arginine production[6][3]. If you need further details or structured information, specialized databases such as UniProt or BRENDA will provide in-depth molecular and regulatory annotations on N-acetylglutamate kinase.

Other names

NAG kinaseNAGKAcetylglutamate kinaseEC 2.7.2.8