N-acetyltransferase 8 (NAT8)

N-acetyltransferase 8 is an enzyme encoded by the NAT8 gene and is primarily expressed in the kidney and liver[1]. NAT8 resides in the endoplasmic reticulum, where it acts as a lysine N-acetyltransferase, catalyzing the N6-acetylation of lysine residues on various proteins using acetyl-CoA as a donor[1][2][5]. It also acetylates the free alpha-amino group of cysteine S-conjugates, contributing to the formation of mercapturic acids—important for the detoxification and excretion of reactive electrophiles[1][5]. NAT8 is implicated in the regulation of apoptosis and protein homeostasis (notably reticulophagy), and may also influence amyloid beta-peptide secretion through acetylation of BACE1 in neurons[1][5]. Mutations in NAT8 are associated with chronic kidney disease and rare syndromes such as Xia-Gibbs syndrome and iminoglycinuria[1][2].

Other names

N-acetyltransferase 8NAT8ATase2CML1GLAHcml1TSC501TSC510CCNATCamello-like protein 1Cysteinyl-conjugate N-acetyltransferaseProtein-lysine N6-acetyltransferase 8

Acetylation of lysine residues on proteins in the endoplasmic reticulum, Acetylation of cysteine S-conjugates to form mercapturic acids