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Target intelligence / Profile preview
N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD)
- Target
- NAPE-PLD
- Molecular classification
- Enzyme, Hydrolase, Phosphodiesterase, Zinc metallohydrolase
01
Overview
N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) is an enzyme that catalyzes the hydrolysis of N-acyl-phosphatidylethanolamines (NAPEs) to generate bioactive lipid mediators known as N-acylethanolamines or fatty acid ethanolamides (NAEs/FAEs), such as anandamide and oleoylethanolamine. These NAEs are important signaling molecules involved in various physiological processes, including neuronal function, metabolism, and inflammation. It is a major biosynthetic enzyme for NAEs in mammals and regulates levels of endocannabinoids. Alterations or deficiencies in NAPE-PLD can impact neuroprotection.
02
Mechanism of action
Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to generate N-acylethanolamines (NAEs)
03
Biological functions
Lipid metabolismEndocannabinoid synthesisRegulation of food intakeEnergy homeostasisNeuronal survival
04
Disease associations
Neurodegenerative diseaseMetabolic disordersInflammation
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