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N-alpha-acetyltransferase 16, NatA auxiliary subunit (NAA16)
- Target
- NAA16
- Molecular classification
- Enzyme complex subunit, Auxiliary protein, Other (regulatory protein)
01
Overview
N-alpha-acetyltransferase 16 (NAA16) is an auxiliary (non-catalytic) subunit that forms part of the NatA complex, which carries out N-terminal acetylation on proteins during translation in eukaryotic cells[2][7]. This modification helps regulate protein stability, localization, and function. NAA16 assists in ribosome binding and influences apoptotic processes and protein stabilization, serving a regulatory and scaffolding function in the NatA complex[2][3][6]. Another closely related auxiliary subunit in the NatA complex is NAA15, and NAA16 is a paralog of NAA15[2][7]. NAA16 is located in the cytosol[2][6]. It is not a direct enzymatic target for pharmacological agents, and no drugs or biomarkers are currently associated specifically with NAA16. There are no known spelling errors or missing information based on current gene/protein knowledge and nomenclature[2][6][7].
- Other names
- NAA16NARG1L
02
Biological functions
Co-translational N-terminal protein acetylationRibosome bindingNegative regulation of apoptosisProtein stabilization
03
Disease associations
Other (no clear direct linkage to specific diseases as an independent factor; protein acetylation may contribute to cancer, neurodegeneration, and other diseases indirectly, but no established direct role of NAA16 itself)
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