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N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35)
- Target
- NAA35
- Molecular classification
- Enzyme, Other (NatC auxiliary protein), Histone modification (N-terminal acetyltransferase complex)
01
Overview
N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) is a cytoplasmic protein encoded by the NAA35 gene in humans and is a component of the N-terminal acetyltransferase C (NatC) complex[2][3][5]. This auxiliary subunit does not have catalytic activity itself but is essential for the function of the NatC complex, which acetylates the N-terminal methionine of substrate proteins—a critical post-translational modification influencing protein stability, localization, and function[3][4][8]. Alternative splicing results in at least two isoforms; the protein is widely conserved across species and is reported in mammals, birds, and amphibians[1][5][6]. Though it is involved in fundamental cellular processes like regulating apoptosis and cell proliferation, there is currently little evidence for direct drug targeting, biomarker usage, or major involvement as a therapeutic target in human disease[5][6].
- Other names
- NAA35MAK10MAK10PEGAPbA379P1.1protein MAK10 homologcorneal wound healing-related proteinembryonic growth-associated protein homologMAK10 homologamino-acid N-acetyltransferase subunitN-alpha-acetyltransferase 35, NatC auxiliary subunit
02
Biological functions
N-terminal acetylation of proteinsProtein modificationNegative regulation of apoptotic processSmooth muscle cell proliferation
03
Disease associations
Other (no major disease association reported; one alias relates to corneal wound healing, but no direct linkage to specific diseases such as cancer, inflammation, or neurodegeneration is described in main sources)
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