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N-glycolyl-GM3 ganglioside
- Molecular classification
- Glycosphingolipid, Ganglioside, Tumor-associated antigen
01
Overview
N-glycolyl-GM3 ganglioside is a sialic acid-containing glycosphingolipid found primarily in tumors. It differs from the common GM3 ganglioside by possessing N-glycolylneuraminic acid (Neu5Gc) instead of N-acetylneuraminic acid (Neu5Ac). Due to its tumor-specific expression, it serves as a valuable target for cancer immunotherapy. It modulates immune function by impairing dendritic cell differentiation and reducing CD4 expression in T cells, contributing to tumor immune escape. Monoclonal antibody 14F7 specifically recognizes N-glycolyl-GM3, making it a potential agent for targeted therapy.
- Other names
- NeuGc-GM3N-glycolyl GM3GM3(NeuGc)
02
Mechanism of action
Antibody-mediated cytotoxicity (potential, via antibodies like 14F7)
03
Biological functions
ImmunomodulationCell signalingMembrane organizationAntigen presentation
04
Disease associations
CancerNeuroblastomaMelanomaLung cancerEwing sarcoma family tumors
05
Safety considerations
Potential for off-target effects if immunotherapy targets cross-react with other glycolipids or tissuesImmunogenicity of NeuGc in humans (potential for antibody response against NeuGc-containing tissues)
06
Biomarkers
N-glycolyl-GM3 expression level in tumor tissue
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