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Target intelligence / Profile preview
N-methyl-D-aspartate glutamate receptor (NMDAR)
- Target
- NMDAR
- Molecular classification
- Ionotropic glutamate receptor, Ligand-gated ion channel
01
Overview
The N-methyl-D-aspartate (NMDA) receptor is a subtype of ionotropic glutamate receptors, which are the primary mediators of excitatory neurotransmission in the central nervous system. It plays a critical role in synaptic plasticity, learning, memory formation, and overall brain development. Abnormal NMDA receptor function has been implicated in various neurological disorders. Hypofunction is associated with schizophrenia spectrum disorders due to impaired synaptic transmission/plasticity, while hyperfunction/excessive activation can lead to excitotoxic neuronal death seen in stroke/traumatic brain injury.
- Other names
- NMDA receptorN-methyl-D-aspartate receptor
02
Mechanism of action
Channel blocker; Agonist; Allosteric modulator
03
Biological functions
Synaptic plasticityLearning and memoryNeurodevelopmentExcitatory neurotransmission
04
Disease associations
Schizophrenia spectrum disordersStrokeTraumatic brain injuryNeurodegenerative disease
05
Safety considerations
ExcitotoxicityHypofunction leading to impaired synaptic transmission/plasticity
06
Interacting drugs
Ketamine
6 more in the full profile.
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