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Target intelligence / Profile preview
N-methyl-D-aspartate Receptor 3A Subunit (GluN3A)
- Target
- GluN3A
- Molecular classification
- Receptor, Ion channel, NMDA Receptor Subunit
01
Overview
The N-methyl-D-aspartate receptor 3A subunit (GluN3A) is a component of NMDA receptors, which are ionotropic glutamate receptors mediating excitatory neurotransmission. Unlike canonical NMDA receptors, GluN1-GluN3 receptors are activated solely by glycine. They exhibit reduced single-channel conductance, low calcium permeability, and low voltage-dependent sensitivity to magnesium block. GluN3A plays specialized roles in neuronal signaling distinct from typical synaptic plasticity functions, including regulation of neuronal excitability, modulation of circuit function, involvement in dendritic spine development, and participation in PPP2CB-NMDAR mediated signaling pathways.
- Other names
- Glutamate [NMDA] receptor subunit 3AGRIN3A
02
Mechanism of action
Glycine-gated ion channel modulation
03
Biological functions
Regulation of neuronal excitabilityModulation of circuit functionInvolvement in dendritic spine developmentPPP2CB-NMDAR mediated signalingSynaptic transmission
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