N-myc downstream-regulated gene 3 protein (NDRG3)

N-myc downstream-regulated gene 3 protein (NDRG3) is a nonenzymatic member of the α/β-hydrolase fold protein family and belongs to the NDRG (N-myc downstream-regulated gene) family[1][2][3]. NDRG3 is structurally similar to other α/β-hydrolases but lacks enzymatic activity due to substitutions in the catalytic triad and steric hindrance at the active site[1][2]. Functionally, NDRG3 is strongly implicated in cellular proliferation, differentiation, hypoxia-induced metabolic signaling, and DNA repair, especially in the context of cancer and male gamete development[1][2][3]. Its expression is regulated by oxygen and lactate levels, with prominent roles in the ERK and β-catenin signaling pathways during cancer progression and spermatogenesis[2][3]. NDRG3 also influences anti-apoptotic signaling (by regulating adenosine A2a receptor activity), metastasis, and cellular responses to hypoxia. While there are currently no specific drugs targeting NDRG3 directly, its role in these processes makes it a potential therapeutic target and biomarker in oncology and reproductive biology[1][2][3].

Other names

Protein NDRG3NDRG3N-myc downstream-regulated gene 3 protein

Not directly targeted by known drugs; indirect roles include lactate-mediated signaling and modulation of ERK1/2, β-catenin, HIF-1α pathways. May be regulated in context of cancer therapy by influencing hypoxic response (HIF pathway).