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Target intelligence / Profile preview
N-myc proto-oncogene protein (N-Myc)
- Target
- N-Myc
- Molecular classification
- Transcription factor, Proto-oncogene, bHLH protein
01
Overview
N-myc proto-oncogene protein is a transcription factor encoded by the *MYCN* gene. It plays a critical role in embryonic development and cell growth/division. Amplification or overexpression of *MYCN* is strongly associated with neuroblastoma and other cancers. Mutations or deletions are linked to Feingold syndrome type 1. It functions by dimerizing with other bHLH proteins to bind DNA and regulate target gene transcription. N-Myc is considered an important therapeutic target.
- Other names
- N-MYCbHLHe37MYCNOTMYCN_HUMANv-myc avian myelocytomatosis viral related oncogene (neuroblastoma derived)pp65/67Neuroblastoma-derived v‑myc avian myelocytomatosis viral related oncogene
02
Mechanism of action
Indirect strategies include targeting mRNA or regulatory partners.
03
Biological functions
Transcription regulationCell proliferationApoptosisEmbryonic developmentNeurodevelopmentRegulation of gene expression
04
Disease associations
CancerNeuroblastomaFeingold syndrome type 1Prostate cancer
05
Safety considerations
Direct inhibition remains challenging due to structural features.
06
Biomarkers
MYCN amplification in neuroblastoma
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