N-terminal pro-brain natriuretic peptide (NT-proBNP)

N-terminal pro-brain natriuretic peptide (NT-proBNP) is a non-active peptide fragment derived by cleavage of proBNP in cardiomyocytes in response to myocardial wall stress. While NT-proBNP itself does not exert biological effects, its concentration in plasma correlates closely with cardiac function, and it is extensively used in clinical practice as a biomarker for heart failure diagnosis, prognosis, and monitoring, as well as risk stratification for cardiovascular and some cerebrovascular events. Clearance is primarily renal, and levels are affected by kidney function, age, and other systemic conditions.

Other names

N-terminal pro-B-type natriuretic peptideNT-proBNPAmino-terminal proBNPN-terminal prohormone of brain natriuretic peptide

Not applicable; NT-proBNP is not a direct drug target. Its levels reflect cardiac wall stress and neurohormonal activity.