Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Protein N-terminal Methyltransferase 1 (NTMT1)
- Target
- NTMT1
- Molecular classification
- Enzyme, Methyltransferase, Protein methyltransferase
01
Overview
Protein N-terminal Methyltransferase 1 (NTMT1) is a protein methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the α-amino group at the N-terminus of specific proteins with an exposed [Ala/Gly/Ser]-Pro-Lys motif. It plays a critical role in regulating protein-DNA interactions, mitosis, chromosome segregation, and DNA repair processes. NTMT1 is overexpressed in various cancers and is considered a potential anticancer target. Inhibition of NTMT1 leads to mitotic defects and impaired DNA repair.
- Other names
- N-terminal Xaa-Pro-Lys N-methyltransferase 1NRMT1METTL11A
02
Mechanism of action
Inhibition of NTMT1-mediated methylation
03
Biological functions
Chromosome segregation during mitosisDNA damage responseProtein-DNA interactionsRegulation of protein function via methylation
04
Disease associations
CancerGastrointestinal cancersMalignant melanomaColorectal cancerBrain cancer
05
Safety considerations
Mitotic defectsDevelopmental issuesImpaired DNA repair capacity
Beyond the preview
Go deeper on Protein N-terminal Methyltransferase 1 (NTMT1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Protein N-terminal Methyltransferase 1 (NTMT1).