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Target intelligence / Profile preview
N-type Voltage-Gated Calcium Channel (CaV2.2)
- Target
- CaV2.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel, High-voltage-activated calcium channel
01
Overview
N-type voltage-gated calcium channels (CaV2.2) are a subtype of high-voltage-activated (HVA) calcium channels predominantly found in the nervous system, especially at presynaptic nerve terminals and dendrites, as well as in neuroendocrine cells. These channels play a crucial role in mediating rapid calcium influx that triggers neurotransmitter release, synaptogenesis, gene expression, and are essential for normal synaptic transmission. They are validated targets for pain management and potential targets for neurological disorders involving synaptic dysfunction or hyperexcitability.
02
Mechanism of action
Inhibition of N-type voltage-gated calcium channels, preventing calcium influx and subsequent neurotransmitter release.
03
Biological functions
Calcium ion transportNeurotransmitter releaseHormone releaseSynaptic transmissionSynaptogenesisGene expression
04
Disease associations
PainNeurological disordersSynaptic dysfunctionHyperexcitability
05
Interacting drugs
ω-Conotoxins
1 more in the full profile.
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