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Target intelligence / Profile preview
N-type Voltage-Gated Calcium Channel Alpha 1B Subunit (Cav2.2)
- Target
- Cav2.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The N-type voltage-gated calcium channel alpha 1B subunit (Cav2.2), encoded by the CACNA1B gene, is a pore-forming protein essential for the function of N-type calcium channels. These channels are primarily found in neurons and neuroendocrine cells and play critical roles in neurotransmitter release, neuronal excitability, and pain pathways. Mutations or dysfunctions in this gene/protein have been associated with neurological disorders.
- Other names
- CACNA1BBIIICACNL1A5CACNNDYT23α1B
02
Mechanism of action
Blocks Ca²⁺ influx through Cav2.2/N-channels to modulate synaptic transmission or relieve pain symptoms
03
Biological functions
Neurotransmitter releaseModulation of neuronal excitabilityCalcium signalingRegulation of hormone secretion
04
Disease associations
PainNeurological disordersDystoniaEpilepsy
05
Safety considerations
Severe chronic pain treatment requires careful monitoring due to potential side effects of ω-conotoxins.
06
Interacting drugs
ω-conotoxins
1 more in the full profile.
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