Target intelligence / Profile preview

N1-acetylpolyamine oxidase

Molecular classification: Enzyme, Oxidoreductase, Flavoenzyme

Overview

N1-acetylpolyamine oxidase (EC 1.5.3.13) is a flavoenzyme that catalyzes the oxidation of N1-acetylated polyamines, playing a key role in polyamine back-conversion. It is localized to peroxisomes and requires FAD as a cofactor. Its activity is implicated in cancer biology and drug resistance, making it a potential target for anticancer drug development.

Other names: hPAO-1mPAOAPAOPAOX

Mechanism of action

Oxidation of N1-acetylated polyamines

Biological functions

Polyamine catabolismPolyamine back-conversionRegulation of polyamine levelsCell growthCell proliferation

Disease associations

CancerDrug resistance

Safety considerations

Potential for off-target effectsDevelopment of resistance mechanisms

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