N6-methyladenosine-containing RNA (m6A-containing RNA)

N6-methyladenosine-containing RNA refers to RNA molecules in which certain adenosine nucleotides are chemically modified by methylation at the nitrogen-6 position (m6A). This epitranscriptomic mark is reversible and regulates almost every stage of RNA metabolism, including splicing, export, translation, and decay, by influencing the binding of specific proteins ("readers," "writers," and "erasers") that control mRNA and non-coding RNA fate. While the m6A modification is not itself a drug target, its regulatory proteins are emerging therapeutic targets, particularly in cancer and other diseases involving RNA dysregulation[1][2][3][4][7][8].

Other names

m6A-modified RNAm6A-containing RNAN6-methyladenosine-modified RNA

Not applicable directly. For drugs targeting the pathway: inhibition of m6A methyltransferase (writer) activity or demethylase (eraser) activity, altering m6A abundance and downstream gene expression[3][7].