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Na+-dependent system B0 transporter (B0AT1)

Target: B0AT1
Molecular classification: Solute Carrier Family 6 (SLC6), Transporter

Overview

The Na+-dependent system B0 transporter (B0AT1/SLC6A19) is a broad-spectrum neutral amino acid transporter that utilizes the sodium gradient to drive the uptake of neutral amino acids. It is primarily expressed in the small intestine and kidney, where it mediates the luminal transport of neutral amino acids. Defects in this transporter lead to Hartnup disease.

Other names: SLC6A19B0AT1Sodium-dependent neutral amino acid transporter 1System B0

Mechanism of action

Sodium-coupled transport of neutral amino acids

Biological functions

Neutral amino acid transportNutrient absorptionAmino acid reabsorptionSodium-dependent transport

Disease associations

Hartnup disease

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