Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Na+-taurocholate cotransporting polypeptide (NTCP)
- Target
- NTCP
- Molecular classification
- Transporter, Solute carrier family 10 member 1
01
Overview
Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1, is a sodium-dependent transporter protein predominantly expressed in the basolateral membrane of hepatocytes. It plays a central role in hepatic uptake of bile acids, steroid hormones, and thyroid hormones, and also functions as a receptor for hepatitis B and D viruses.
- Other names
- SLC10A1Sodium taurocholate cotransporting polypeptide
02
Mechanism of action
Inhibition of NTCP-mediated transport and/or viral entry
03
Biological functions
Bile acid transportSteroid hormone transportThyroid hormone transportHBV/HDV receptor
04
Disease associations
Inherited hypercholanemiaHepatitis BHepatitis DDiet-induced obesityCholestatic liver injury
05
Safety considerations
Elevated serum/plasma levels of bile saltsCompensatory mechanisms by other transporters
06
Interacting drugs
Myrcludex B
8 more in the full profile.
07
Biomarkers
Plasma bile salt levelsNTCP expression levels
Beyond the preview
Go deeper on Na+-taurocholate cotransporting polypeptide (NTCP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Na+-taurocholate cotransporting polypeptide (NTCP).