NACHT and WD repeat domain-containing protein 2 (NWD2)

NACHT and WD repeat domain-containing protein 2 (NWD2) is a multidomain protein characterized by the presence of a NACHT domain and multiple WD-repeat motifs[1][5][8]. It is a member of the STAND subfamily of P-loop NTPases and is classified as a WD repeat-containing protein, which is a group involved in protein-protein interactions and diverse regulatory cellular functions[3][7]. In mouse, NWD2 expression is mostly confined to neurons in the medial habenular nucleus, with lower levels in brain regions such as the piriform cortex and hippocampus[4]. The exact biological role in humans is not fully established, but by homology and family function, it is likely involved in specialized neuronal signal transduction processes. There is no evidence that NWD2 is a therapeutic target or receptor, nor are there known drugs that interact with it. NWD2 is primarily a gene product involved in cellular signaling rather than a classic drug target like a receptor, enzyme, or ion channel. It is often referenced by its abbreviation (NWD2) and is occasionally listed under older gene symbols such as KIAA1239[1][5]. It has not been implicated in common human diseases, and its function remains under characterization in the neuroscience field.

Other names

KIAA1239Leucine-rich repeat and WD repeat-containing protein KIAA1239NACHT and WD repeat domain containing 2ENSG00000174145

Not applicable (no known targeted drugs).