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Target intelligence / Profile preview
NACHT LRR PYD domains-containing protein 3 (NLRP3)
- Target
- NLRP3
- Molecular classification
- Pattern Recognition Receptor (PRR)
01
Overview
NLRP3 is a pattern recognition receptor (PRR) within the innate immune system that recognizes pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Upon activation, NLRP3 oligomerizes, recruits the adaptor protein ASC, and activates caspase-1, leading to the maturation and release of pro-inflammatory cytokines IL-1β and IL-18. Dysregulation of NLRP3 contributes to various autoinflammatory and metabolic diseases.
- Other names
- CIAS1FCAS1NALP3PYPAF1
02
Mechanism of action
Inhibition of ATP-binding/hydrolysis in the NACHT domain, preventing NLRP3 activation and inflammasome assembly.
03
Biological functions
Innate ImmunityInflammasome AssemblyCytokine MaturationRecognition of PAMPs and DAMPs
04
Disease associations
Cryopyrin-associated periodic syndromes (CAPS)Gouty ArthritisNeurodegenerative DisordersType II Diabetes MellitusInflammation
05
Safety considerations
Potential for immunosuppression if NLRP3 inhibition is excessive.
06
Interacting drugs
MCC950/CRID3
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