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Target intelligence / Profile preview
NAD(P)H dehydrogenase (quinone) (NQO1)
- Target
- NQO1
- Molecular classification
- Enzyme, Flavoprotein, Oxidoreductase
01
Overview
NAD(P)H dehydrogenase (quinone) (NQO1) is a cytosolic flavoprotein enzyme that catalyzes the two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. This reaction is crucial for detoxifying quinones and preventing the formation of semiquinone radicals and reactive oxygen species, which can be damaging to cells. It plays a key role in redox regulation and protein stability, and its altered expression is linked with disease susceptibility.
- Other names
- DT-diaphoraseMenadione reductaseAzoreductaseDTD
02
Mechanism of action
Two-electron reduction of quinones to hydroquinones, bypassing semiquinone formation.
03
Biological functions
DetoxificationRedox regulationProtein stabilityAntioxidant defense
04
Disease associations
CancerAlzheimer’s diseaseNeurodegenerative disorders
05
Safety considerations
Genetic polymorphisms affect drug responseAltered expression linked to cancer susceptibility
06
Interacting drugs
Dicoumarol
1 more in the full profile.
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